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12-ALPHA-HYDROXYLASE
Descriptors Found:
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DeCS
Descriptor
English
:
Steroid 12-alpha-Hydroxylase
Descriptor
Spanish
:
Esteroide 12-alfa-Hidroxilasa
Descriptor
Portuguese
:
Esteróide 12-alfa-Hidroxilase
Synonyms
English
:
12-alpha-Hydroxylase
Steroid 12-Monooxygenase
Sterol 12-alpha-Hydroxylase
Tree Number:
D08.244.453.915.730
D08.811.682.690.708.170.915.730
D08.811.682.690.708.783.730
D12.776.422.220.453.915.730
Definition
English
:
A
liver
microsomal cytochrome P450 enzyme that catalyzes the 12-alpha-hydroxylation of a broad spectrum of
sterols
in the presence of molecular
oxygen
and
NADPH-FERRIHEMOPROTEIN REDUCTASE
. This enzyme, encoded by CYP8B1gene, converts 7-alpha-hydroxy-4-cholesten-3-one to 7-alpha-12-alpha-dihydroxy-4-cholesten-3-one and is required in the synthesis of
BILE
ACIDS
from
cholesterol.
History Note
English
:
2003 (1978)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
29288
Unique Identifier:
D013253
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS