Search on: SUCCINATE-SEMIALDEHYDE DEHYDROGENASE 
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Descriptor English:   Succinate-Semialdehyde Dehydrogenase 
Descriptor Spanish:   Succionato-Semialdehído Deshidrogenasa 
Descriptor Portuguese:   Succinato-Semi-Aldeído Desidrogenase 
Tree Number:   D08.811.682.657.163.843
Definition English:   An enzyme that plays a role in the GLUTAMATE and butanoate metabolism pathways by catalyzing the oxidation of succinate semialdehyde to SUCCINATE using NAD+ as a coenzyme. Deficiency of this enzyme, causes 4-hydroxybutyricaciduria, a rare inborn error in the metabolism of the neurotransmitter 4-aminobutyric acid (GABA). 
History Note English:   2006(1980); use ALDEHYDE OXIDREDUCTASES 1977-1979 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DF deficiency
DU diagnostic use DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   50619 
Unique Identifier:   D050644 

Occurrence in VHL:
 

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