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STATHMIN
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DeCS
Descriptor
English
:
Stathmin
Descriptor
Spanish
:
Estatmina
Descriptor
Portuguese
:
Estatmina
Tree Number:
D12.776.220.600.450.480
D12.776.624.664.700.957
D12.776.744.772
Definition
English
:
A ubiquitous phosphoprotein that serves as an intracellular substrate for a variety of
SIGNAL TRANSDUCTION
PATHWAYS.
PHOSPHORYLATION
of
stathmin
occurs during
CELL CYCLE
progression, and
stathmin
functions as a microtubule-destabilizing protein that promotes MICROTUBULE depolymerization during
INTERPHASE
and late
MITOSIS
.
Stathmin
is expressed at very high levels in a variety of human CANCERS.
History Note
English
:
2006(1987)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
50938
Unique Identifier:
D050777
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS