Search on: SODIUM POTASSIUM CHLORIDE SYMPORTER INHIBITORS 
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Descriptor English:   Sodium Potassium Chloride Symporter Inhibitors 
Descriptor Spanish:   Inhibidores del Simportador de Cloruro Sódico y Cloruro Potásico 
Descriptor Portuguese:   Inibidores de Simportadores de Cloreto de Sódio e Potássio 
Tree Number:   D27.505.519.562.906
Definition English:   Agents that inhibit SODIUM-POTASSIUM-CHLORIDE SYMPORTERS which are concentrated in the thick ascending limb at the junction of the LOOP OF HENLE and KIDNEY TUBULES, DISTAL. They act as DIURETICS. Excess use is associated with HYPOKALEMIA and HYPERGLYCEMIA. 
Indexing Annotation English:   coordinate with DIURETICS if pertinent
History Note English:   2006 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DU diagnostic use
EC economics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UR urine
Record Number:   51201 
Unique Identifier:   D049994 

Occurrence in VHL: 		 

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