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DEMETHYL EPIPODOPHYLLOTOXIN ETHYLIDINE GLUCOSIDE
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DeCS
Descriptor
English
:
Etoposide
Descriptor
Spanish
:
Etopósido
Descriptor
Portuguese
:
Etoposídeo
Synonyms
English
:
Demethyl Epipodophyllotoxin Ethylidine Glucoside
Tree Number:
D02.455.426.559.847.638.960.675.250
D04.615.638.960.675.250
D09.408.348.275
Definition
English
:
A semisynthetic derivative of
PODOPHYLLOTOXIN
that exhibits antitumor activity.
Etoposide
inhibits
DNA
synthesis by forming a complex with topoisomerase II and
DNA
. This complex induces breaks in double stranded
DNA
and prevents repair by topoisomerase II binding. Accumulated breaks in
DNA
prevent entry into the mitotic phase of
cell division
, and
lead
to
cell death
.
Etoposide
acts primarily in the G2 and S phases of the
cell cycle.
Pharmacological Action:
Antineoplastic Agents, Phytogenic
History Note
English
:
87(81); was see under PODOPHYLLOTOXIN 1981-86; was VP 16-213 see under PODOPHYLLOTOXIN 1976-80
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DU
diagnostic use
EC
economics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
5143
Unique Identifier:
D005047
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS