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CYCLIN-DEPENDENT KINASE INHIBITOR P21
Descriptors Found:
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DeCS
Descriptor
English
:
Cyclin-Dependent Kinase Inhibitor p21
Descriptor
Spanish
:
Inhibidor p21 de las Quinasas Dependientes de la Ciclina
Descriptor
Portuguese
:
Inibidor de Quinase Dependente de Ciclina p21
Tree Number:
D12.644.360.225.500
D12.776.167.187.500
D12.776.476.225.500
D12.776.624.776.355.500
Definition
English
:
A cyclin-dependent kinase inhibitor that mediates TUMOR SUPPRESSOR PROTEIN P53-dependent
CELL CYCLE
arrest. p21 interacts with a range of
CYCLIN-DEPENDENT KINASES
and associates with
PROLIFERATING CELL NUCLEAR ANTIGEN
and
CASPASE 3.
Pharmacological Action:
Protein Kinase Inhibitors
History Note
English
:
2006(1993)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
50931
Unique Identifier:
D050759
Occurrence in VHL
:
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