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CALCIMYCIN
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DeCS
Descriptor
English
:
Calcimycin
Descriptor
Spanish
:
Calcimicina
Descriptor
Portuguese
:
Calcimicina
Tree Number:
D03.438.221.173
Definition
English
:
An ionophorous, polyether antibiotic from
Streptomyces
chartreusensis. It binds and transports
cations
across
membranes
and uncouples
oxidative phosphorylation
while inhibiting ATPase of rat
liver
mitochondria
. The substance is used mostly as a biochemical tool to study the
role
of divalent
cations
in various biological systems.
Pharmacological Action:
Anti-Bacterial Agents
Ionophores
History Note
English
:
91(75); was A 23187 1975-90 (see under ANTIBIOTICS 1975-83)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DU
diagnostic use
EC
economics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
29212
Unique Identifier:
D000001
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS