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Descriptor English:   alpha-Fetoproteins 
Descriptor Spanish:   alfa-Fetoproteínas 
Descriptor Portuguese:   alfa-Fetoproteínas 
Synonyms English:   AFP
Fetuins  
Tree Number:   D12.776.320.050
D23.101.840.050
Definition English:   The first alpha-globulins to appear in mammalian sera during development of the embryo and the dominant serum proteins in early embryonic life. They reappear in the adult serum during certain pathologic states, primarily hepatocellular carcinoma. They may also be elevated in the amniotic fluid and maternal serum during pregnancy in ANENCEPHALY. 
Indexing Annotation English:   /biosyn /physiol permitted
See Related English:   Anencephaly
 
History Note English:   96; was ALPHA FETOPROTEINS 1975-95 (see under FETAL GLOBULINS 1975-76) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   23940 
Unique Identifier:   D000509 

Occurrence in VHL:
 

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